ITMAT Home » CTRC Home

Welcome to the Clinical and Translational Research Center (CTRC)

The Clinical and Translational Research Center (CTRC) was formed with the receipt of the Clinical and Translational Science Award (CTSA), an NIH Roadmap initiative. The CTRC has child and adult specific components at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania, respectively, as well as joint components. The CTRC merged the General Clinical Research Centers (GCRCs) at both institutions, and introduced new programs and services. The goal of the CTRC is to provide the resources, environment, operations, and training to support and promote high-quality clinical and translational research by qualified investigators.

Important Information for PI's Submitting External Grant Applications

It is extremely important for investigators to contact the CTRC Administration when preparing grant budgets and submissions. The CTRC charges for services and these costs must be included in all budgets. The CTRC Administrative Director can provide this information. In addition, it is strongly recommended that investigators include a letter of support from the appropriate CTRC Program Director when their grant submission proposes the use of the CTRC. For a letter of support for a study utilizing the adult CTRC, contact the Program Director, Karen Teff, PhD, at or by calling 267-519-4860. For a letter from the pediatric CTRC Program Director, contact Carole Marcus, MBBCh, at or by calling 267-426-5842. CTRC Administrative Directors are Charles Molli (adult) at (215-898-7335) and Ronnie Mazzaccaro (pediatric) at (215-590-2215). In addition to costs of services, CTRC Administrators can provide PI's with information to support their grant budget justifications.


CTRC Core Services are extensive and include the following:

  • Translational Core Laboratories (TCL) » Lab subcores include Specimen Collection/Point of Care Testing/Sample Disposition Lab, Molecular Biology and Cell Culture Labs, and the Biochemistry/Genetics Lab;
  • Study Design and Biostatics (SDAB) » provides planning and analytic services, which include study design, sample size estimation, analysis planning, as well as production of statistical reports and graphical displays.
  • Investigational Drug Service » to prepare investigational agents for human use;
  • Research Nurse Core (RNC) » Support for inpatient and outpatient clinical research by nurses with extensive experience
  • Office of Human Subject Recruitment and Protection (OHSRP) provides consultation and guidance to the research community on all issues related to recruitment and protection;
  • Office of Human Research: office designed to provide infrastructural and logistical support to investigators conducting translational and clinical research within the framework of the CTSA;
  • Ultrasound Research Laboratory:The Department of Radiology at the University of Pennsylvania houses a state-of-the-art Ultra Sound Research Laboratory for conducting clinical and pre-clinical research. These resources are availabile to investigators for clinical research at the University of Pennsylvania.

Clinical Core Services:

The CTRC supports the research of more than 300 different principal investigators from HUP and CHOP All protocols must first be approved by the CTRC Resource Committees.



You must be an ITMAT member to receive CTSA supported services.
All publications, press releases or other documents citing results from NIH-grant supported
research much acknowledge the NIH grant support.


» Top