LeadershipGarret A. FitzGerald, MD | Principal Investigator | Website » | Website »
Dr. FitzGerald has overall responsibility for the administrative guidance of the program, its structural coherence and integration and scientific direction. Dr. FitzGerald is a well established investigator in the translational therapeutics of prostaglandins and related bioactive lipids. His work ranges from the use of cellular and animal model systems through detailed study of disease mechanism and drug action in humans to involvement in epidemiological analyses and randomized clinical trials. His work integrates a variety of technology platforms including the use of mass spectrometry to identify and develop quantitative assays for biomarkers; emerging quantitative methodology in lipidomics and proteomics; genomics and bioinformatics approaches to analysis and integration of translational data sets. He serves as Director of the Institute for Translational Medicine and Therapeutics (ITMAT), Assistant Dean for Translational Research in the School of Medicine, Chairman of Pharmacology, and was previously PI of the Penn GCRC. Dr. FitzGerald has received many distinctions including honorary doctorates from Edinburgh, Dublin and Frankfurt, the Boyle and Harvey Medals, the J. Allyn Taylor and Cameron Prizes and the Phillips, Hertz, and ASPET awards.
Tom Curran, Ph.D., FRS | Co-Director | Website »
Tom Curran, Ph.D., FRS is the Deputy Director of the Children's Hospital of Philadelphia Research Institute, Professor of Pathology and Laboratory Medicine and Professor of Cell and Developmental Biology, in the Perelman School of Medicine at the University of Pennsylvania and Associate Director of Translational Genomics in the Penn Genome Frontiers Institute (PGFI). The goal of Dr. Curran's research program is to uncover new approaches to the treatment of pediatric brain tumors by integrating an understanding of normal brain development with the molecular genetics of brain tumors. To address these aims, his group pursues basic neurobiology questions concerning the molecular bases of neurodevelopment and function, in parallel with studies on human brain tumors and mouse models of pediatric brain tumors. Dr. Curran served as President of the American Association of Cancer Research in 2001 and on the Board of Scientific Advisors of the National Cancer Institute from 2000-2005. In 2005 he was elected as a fellow of the Royal Society and in 2009 he was elected to the Institute of Medicine of the National Academies of Science, USA. In 2012, he was elected as a member of the American Academy of Arts and Sciences.
Glen Gaulton, PhD | Co-Director | Website » | Website »
Dr. Gaulton is the Executive Vice Dean, Chief Scientific Officer, and Professor of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine. Dr. Gaulton will serve as a Co-Program Director of the CTSA with operational responsibility for the education and regulatory and compliance sections. Dr. Gaultonís responsibilities are to oversee both the Office of the Executive Vice Dean and his active research laboratory. The Executive Vice Dean and Chief Scientific Officer has operational, planning, and financial responsibility for the academic component of all research endeavors and research training missions within the School. This includes the Offices of the Executive Vice Dean, Combined Degree and Physician Scholar Programs, Biomedical Graduate Studies, Postdoctoral Programs, Masters Programs, Human Research, Corporate Alliances, and Research Program Development. Dr. Gaulton also holds prime responsibility for interface on research and research education with the partners in the CTSA application, including the schools within Penn, Childrenís Hopsital of Philadelphia (CHOP), The Wistar Institute (WI), University of the Sciences in Philadelphia (USIP), and the partner undergraduate institutions.
Dr. Gaulton's research interests are in the areas of lymphocyte growth and viral pathogenesis. He has published eighty-five articles and directly supervised the research training of over twenty graduate students and fellows. Dr. Gaulton has received numerous awards for teaching and research, including the Berwick Memorial Teaching Award, the Lindback Award, the Harry Weaver Neuroscience Scholar Award from the National Multiple Sclerosis Society, and the Leukemia Society Scholar Award.
Carole Marcus, MBBCh | Co-Director | Website »
Dr. Marcus is Co-Program Director of the CTSA, and Co-Director of the Clinical and Translational Research Center. She served as the Children's Hospital of Philadelphia's (CHOP) GCRC Program Director from 2003-2006, and is an Associate Director of ITMAT. Dr. Marcus is a Professor of Pediatrics at the University of Pennsylvania and Director of the Sleep Center at Children's Hospital of Philadelphia. Dr. Marcus is a Deputy Editor for the journal Sleep, and has had leadership roles in the Sleep Research Society, American Thoracic Society and American Academy of Pediatrics. Her research is focused on developmental changes in upper airway physiology and the pathophysiology of pediatric obstructive sleep apnea.
Daniel J. Rader, MD | Co-Director | Website »
Dr. Rader has direct responsibility for direction of the Penn component of the Clinical and Translational Research Center (CTRC) and, together with Dr. Marcus of CHOP, of the cores related to the CTRC as described in the proposal. They both report to Dr. FitzGerald in this capacity. Dr Rader was previously the Program Director of the Penn GCRC and is Associate Director of ITMAT. Dr. Rader is the Cooper-McClure Professor of Medicine, Pharmacology and Pathology and Lab Medicine and Director of Preventive Cardiovascular Medicine. Dr. Rader is well known for his work which integrates studies in cellular systems, mouse models and humans and focuses on the mechanisms by which LDL promotes atherosclerosis and HDL protects against it. His discovery of endothelial lipase opened a new aspect in the field of lipoprotein biology and he is a leader in translational therapeutics for lipid disorders and atherosclerosis. Dr. Rader has also played a leading role in education in clinical and translational research and is PI of a K12 Award. He holds numerous distinctions and awards in the area of Translational Research, including from American Heart Association, the Burroughs Wellcome Fund and the Doris Duke Charitable Foundation.
Brian L. Strom, MD, MPH | Co-Director | Website »
Dr. Strom will take responsibility for the programs and cores related to epidemiology, population sciences and dissemination of information (bedside-to-population translation). He will report to Dr. FitzGerald in this capacity. Dr. Strom is a prominent expert in clinical epidemiology with a particular focus on the effectiveness and safety of drug therapy. He is PI of an AHRQ CERT award to address this issue in partnership with the FDA and is the author of the primary textbook on Pharmacoepidemiology. Dr. Strom has built a large, diversified and remarkably diversified educational program in clinical epidemiology and biostatistics and had been the PI of the Penn K30 award, which nurtured the emergence of the Masters in Translational Research as well as expanding considerably the impact of the previously established Master of Science in Clinical Epidemiology. Dr. Strom is the Vice Dean of the School of Medicine and the Senior Advisor to the Provost on Global Health Initiatives. Dr. Strom is Director of the Center for Clinical Epidemiology and Biostatistics and Chair of the Department of Biostatistics and Epidemiology. Dr. Strom has received many distinctions. Amongst these, he is a member of the Institute of Medicine.
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