CTSA: Clinical & Translational Science Award


CTSA Leadership

Image

Garret A. FitzGerald, MD, FRS

Principal Investigator
Website
FitzGerald Lab Site
Email: garret@upenn.edu

Dr. FitzGerald has overall responsibility for the administrative guidance of the program, its structural coherence and integration and scientific direction. Dr. FitzGerald is a well established investigator in the translational therapeutics of prostaglandins and related bioactive lipids. His work ranges from the use of cellular and animal model systems through detailed study of disease mechanism and drug action in humans to involvement in epidemiological analyses and randomized clinical trials. His work integrates a variety of technology platforms including the use of mass spectrometry to identify and develop quantitative assays for biomarkers; emerging quantitative methodology in lipidomics and proteomics; genomics and bioinformatics approaches to analysis and integration of translational data sets. He serves as Director of the Institute for Translational Medicine and Therapeutics (ITMAT), Assistant Dean for Translational Research in the School of Medicine, Chairman of Systems Pharmacology and Translational Therapeutics, and was previously PI of the Penn GCRC. Dr. FitzGerald has received many distinctions including the Boyle Medal and the Grand Prix Lefoulon-Delalande of the Institute de France.


Image

Anne Rentoumis Cappola, MD, ScM

Co-Director
Website
Email: acappola@mail.med.upenn.edu

Dr. Cappola is Co-Program Director of the CTSA and Co-Director of the Center for Human Phenomic Science. She is recognized as a leader in translational research at the intersection of endocrinology and geriatrics, combining population-based and mechanistic research studies to identify the hormonal underpinnings of human aging. Her scientific contributions have led to changes in treatment recommendations for thyroid disorders in older individuals. She has also pioneered studies in human subjects that seek to determine the role of endocrine abnormalities in age-associated frailty.She is an elected member of the American Society for Clinical Investigation and the Interurban Clinical Club and an Associate Editor for JAMA. She is Professor of Medicine and Assistant Director of ITMAT.


Image

Dennis R. Durbin, MD, MSCE

Co-Director
Website
Email: durbind@email.chop.edu

Dennis R. Durbin, MD, MSCE is Professor of Pediatrics at The Children’s Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine. He is the Chief Clinical Research Officer at the Children’s Hospital of Philadelphia Research Institute, a member of the Division of Emergency Medicine, and an Associate Scholar at the Center for Clinical Epidemiology and Biostatistics at the School of Medicine. He has been on the University of Pennsylvania faculty for over 20 years as a clinician and scientist. Dr. Durbin is an internationally recognized injury epidemiologist whose research has focused on the prevention of motor vehicle occupant injuries to children and the prevention of teen driver crashes. He has over two decades of experience with traffic safety research and developing the evidence base for child and adolescent traffic safety interventions and extensive experience translating research findings into policy and practice. He has served on the Committee for Injury, Violence and Poison Prevention of the American Academy of Pediatrics during which time he was the lead author on the Academy’s revised policy statement on child passenger safety. His research has been recognized by a number of organizations with several awards, including the Governor’s Highway Safety Association, the Association for the Advancement of Automotive Medicine, Advocates for Highway and Auto Safety, the Maternal and Child Health Bureau, the American Academy of Pediatrics, and the University of Pennsylvania.

In addition, he has mentored over 30 trainees and junior faculty to become physician-scientists, with many now thriving in independent research careers. For the past 6 years, he has overseen the development and implementation of a research mentor training program at the University of Pennsylvania School of Medicine, including developing new content for the curriculum. Nearly 100 faculty have participated in the training which has been uniformly well-received.


Image

Glen N. Gaulton, PhD

Co-Director
Website
Email: gaulton@mail.med.upenn.edu

Dr. Glen Gaulton is Co-Director of the CTSA with responsibility for integration of the program education and training components.  Dr. Gaulton is currently Vice Dean and Director of the Center for Global Health, and Professor of Pathology and Laboratory of Medicine at the University of Pennsylvania Perelman School of Medicine.  In this capacity Dr. Gaulton oversees the full scope of global heath activities in the school with a mission to improve health equity worldwide through improved awareness and access to care, discovery and outcomes based research, and comprehensive educational programs grounded in partnership.  Dr. Gaulton is an experienced investigator and mentor with aligned research interests in the area of viral pathogenesis, early detection of pathogen infection, and outcomes research in global health.  Prior to his current role, he served for 16 years as the lead scientific officer of the Perelman School. In this capacity he supervised all aspects of the School’s research and research training enterprise; here he played a key role in launching the ITMAT and in establishing multiple graduate programs integral to the CTSA.


Image

Carole Marcus, MBBCh

Co-Director
Website
Email: marcus@email.chop.edu

Dr. Marcus is Co-Program Director of the CTSA, Co-Director of the Center for Human Phenomic Science, and Associate Director of ITMAT. Dr. Marcus is a Professor of Pediatrics at the University of Pennsylvania Perelman School of Medicine and Director of the Sleep Center at Children's Hospital of Philadelphia. Dr. Marcus is a Deputy Editor for the journal Sleep, and has had leadership roles in the Sleep Research Society, American Thoracic Society and American Academy of Pediatrics. Her research is focused on developmental changes in upper airway physiology and the pathophysiology of pediatric obstructive sleep apnea.


Image

Emma Meagher, MD

Co-PI
Director, Translational Science Education
Website
Email: emma@upenn.edu

Dr. Meagher directs the Education and Training components of the CTSA. Dr. Meagher's educational interests are in the fields of translational research methodology to graduate, pre, and post doctoral students, and novel modalities for education in pharmacology to undergraduate medical students. To this end she directs the University of Pennsylvania pharmacology curriculum and is Program Director for ITMAT's Translational Research Training Program. Dr. Meagher has held many positions of leadership in national professional and educational program-associated societies including Director at Large for the Board of Directors and Chair of the Education and Mentoring Committee for the Association for Clinical and Translational Science. She serves as Associate Professor of Medicine and Systems Pharmacology and Translational Therapeutics, Executive Chair of the University of Pennsylvania Institutional Review Board, Associate Vice Provost for Human Subjects Research, Associate Dean for Clinical Research, and Associate Dean for Admissions for the Perelman School of Medicine. Dr. Meagher has been the recipient of many awards including the university’s highest teaching honor, the Lindback Award for Medical Education (2005).


Image

Daniel J. Rader, MD

Co-Director
Website
Email: rader@mail.med.upenn.edu

Dr. Rader is the Chair for the Department of Genetics, and the Chief for the Division of Translational Medicine and Human Genetics within the Department of Medicine, Associate Director for the Institute for Translational Medicine and Therapeutics (ITMAT), and Co-Director of the Penn Medicine Biobank. Dr. Rader has used human genetics and model systems to elucidate novel biological pathways in lipoprotein metabolism and atherosclerosis in his research. His lab discovered and characterized the enzyme endothelial lipase, demonstrated its effects on high density lipoproteins (HDL) in mice, and then found that loss-of-function mutations in the gene cause high levels of HDL in humans. He is among the world’s leaders in using both humans and model systems to dissect the functional genomics of human genetic variants associated with plasma lipid traits as well as coronary heart disease. He has had a long interest in Mendelian disorders of lipoprotein metabolism and has a strong translational interest in development of novel therapies for these disorders. He was involved in the identification of the molecular defect in a rare genetic disorder causing very low levels of low density lipoproteins (LDL), which spurred the development of inhibitors of this protein to reduce levels of LDL. Indeed, when one such drug was abandoned by a pharmaceutical firm, he went on to oversee its development for the orphan disease homozygous familial hypercholesterolemia (HoFH), characterized by extremely high levels of LDL and heart disease in childhood. This decade-long endeavor led to FDA and European approval of lomitapide, the first effective medication for the treatment of HoFH. He holds numerous distinctions and awards in the area of Translational Research, including from American Heart Association, the Burroughs Wellcome Fund and the Doris Duke Charitable Foundation. He has been elected to the American Society of Clinical Investigation, to the Association of American Physicians, and to the Institute of Medicine. 


Image

Kevin Volpp, MD, PhD

Co-Director
Website
Email: volpp70@upenn.edu

Dr. Volpp has direct responsibility of oversight of efforts to expand CTSA activity in the population health management space. He is overseeing a new pilot program around the use of mobile technologies and testing ways to use these to increase ongoing patient engagement and patient health. Dr. Volpp is the Director of the LDI Center for Health Incentives and Behavioral Economics, 1 of 2 NIH-funded Centers in Behavioral Economics and health and is well known for pioneering work in the use of financial and social incentives to improve patient engagement and for chronic disease management. He is a Professor at the School of Medicine and the Wharton School and is Vice Chairman of the Department of Medical Ethics and Policy as well as Co-Director of the Penn Medicine Center for Health Care Innovation. He has garnered numerous awards for his research including election into the Institute of Medicine, the British Medical Journal Group Award for Translating Research into Practice, article of the year awards from multiple societies, and a Presidential Early Career Award for Scientists and Engineers. He served on the Editorial Board of the Annals of Internal Medicine and is now a Contributing Writer to JAMA.