ITMAT symposia enlist outstanding speakers from the US and abroad to address topics of direct relevance to translational science.
Launched in September of 2005, the ITMAT monthly seminar series continues to host outstanding role models who pursue translational research, from outside of the Penn community, are invited to lecture in this series, which is being coordinated by Charles Abrams, M.D.
Workshops are conducted throughout the year and focus on key functional areas within ITMAT. These workshops have been coordinated by the leaders of our research programs and cores and address the practicalities of technologies and approaches of relevance to Translational Medicine and Therapeutics.
ITMAT and SomaLogic Symposium
Thursday, October 23, 2014
10-100 Smilow Center For Translational Therapeutics
The SOMAscanTM assay, developed by SomaLogic, is the most powerful protein biomarker discovery tool available today. Penn is the first institution to sign an agreement with SomaLogic to perform SOMAscan at a remote location and the assay is now available through the Translational Core Laboratories on a fee-for-service basis. The SOMAscan assay measures 1129 protein analytes in < 150 µl of human plasma and offers exceptional dynamic range, quantifying proteins that span over 8 logs in abundance (from femtomolar to micromolar), with very low limits of detection and excellent reproducibility. Compared with other proteomics discovery techniques such as mass spectrometry, the SOMAscan is able to provide rapid measurements and comparisons across samples without extensive sample preprocessing. Work in the Penn Translational Core Laboratory has shown very favorable performance characteristics with 96.5% of all proteins showing a coefficient of variation (CV) < 20%. In addition, the SOMAscan assay has proven to be successful in several non-human species. Ideal experimental designs include a comparison of individuals with a phenotype or disease compared with carefully matched controls, or investigation of response to a pharmacologic or other experimental intervention.