Funding Opportunities

 Upcoming Deadlines:



Pilot Grant Application System


TAPITMAT Transdisciplinary Awards Program in Translational Medicine and Therapeutics

 Application due date: Friday, December 2, 2016, at noon.

The Institute for Translational Medicine and Therapeutics (ITMAT) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category. It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion. If you are interested, please visit the membership section of our website for details.

The proposals must center on the translational space – from proof of concept in cells or model systems through to mechanistic studies in humans elucidating human physiology or mechanisms of disease or, in drug development, parsing sources of variability in drug response and/or dose selection in Phase II.  Programs that plan to progress within that space and which deploy technologies and approaches conventionally segregated from each other within the traditional boundaries of academic medicine will be especially favored.  Proposals that focus on translational therapeutics or on bridging the pediatric to adult divide are particularly encouraged.

The proposals are due by December 2, 2016, for a proposal start date of February 1, 2017.

2013 Awardees

We are delighted to announce the sixth round of successful applications for the Institute for Translational Medicine and Therapeutics' (ITMAT) Transdisciplinary Award Program (TAPITMAT), supported by the School of Medicine. The quality of all applications was extremely high and the funding decisions, made by members of the Internal Advisory Board, were extremely difficult.

The selected projects range across the breadth of biology, integrate diverse disciplines and investigators from many schools of Penn, The Children's Hospital of Philadelphia, and the Wistar Institute reflecting their interaction in the context of the Clinical and Translational Science Award. They are uniformly of high scientific quality, interdisciplinary and translational in nature.

ITMAT is delighted with the number and quality of applications responsive to this call for awards and will continue to develop the program further in future years.

Modulating Norepinephrine Transporter Expression in Neuroendocrine Cancer: Towards Enhancing MIBG Radiotherapy
Ann-Marie Chacko, PhD, Department of Radiology, Perelman School of Medicine
Lauren Fishbein, Medicine-Diabetes, Endocrinology, and Metabolism, Perelman School of Medicine
Chunsheng Li, Center for Research on Reproduction and Women's Health, Perelman School of Medicine

Salvinorin A a novel medication for brain hypoxia/ischemia in the perinatal period
Renyu Liu, Anesthesiology and Critical Care, Perelman School of Medicine
Edwin (Ted) Able, Biology, School of Arts and Sciences

Discovering rescuing mutations in Diamond Blackfan Anemia
Philip Mason, Pediatric-Hematology, Perelman School of Medicine
Monica Bessler, Pediatric-Hematology, Perelman School of Medicine
Patrick Warren, Center for Biomedical Informatics, The Children's Hospital of Philadelphia

Activating E3 ubiquitin ligases to treat inflammation and atopic disease.
Paula Oliver, Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia
Michael May, Animal Biology, Veterinary School of Medicine

Novel tPA variant and outcome after pediatric stroke
William Armstead, Anethesiology and Critical Care, Perelman School of Medicine
Susan Marguiles, Neurosurgery, Perelman School of Medicine
Joel Greenberg, Neurology, Perelman School of Medicine
Douglas Smith, Neurosurgery, Perelman School of Medicine
Doug Cines, Pathology and Laboratory Medicine, Perelman School of Medicine

Dual graft enhancing strategy by targeting T cells and the stem cell compartment to improve engraftment and immune recovery in single umbilical cord blood transplantation
Elizabeth Hexner, Medicine-Hematology/Oncology, Perelman School of Medicine
Peter Klein, Medicine-Hematology/Oncology, Perelman School of Medicine
Dale Frank, Pathology and Laboratory Medicine, Perelman School of Medicine


For more information, please visit the ITMAT website.

Garret A. FitzGerald, MD, FRS
Director, ITMAT

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TAPITMAT TBIC Translational Biomedical Imaging Center

 Application due date: Friday, December 2, 2016, at noon.

The Translational Biomedical Imaging Center (TBIC) was established under the leadership of the ITMAT in part "to broaden and accelerate translational imaging research through the development of a center to bring together investigators with diverse backgrounds that contribute to various aspects of imaging science and who share a vision of contributing to the advancement of clinical medicine." Among the approaches adopted by the TBIC to promote the use of imaging technology to facilitate translational research are the support of core facilities, collaborative imaging scientists, and retreats/seminars. Building on this foundation, the TBIC announces a new collaborative pilot grant program to help catalyze collaborations between primary imaging scientists and primary biomedical/clinical researchers that integrate novel imaging approaches to enhance translational science and medicine.

These proposals require at least two Co-Principal Investigators, one investigator whose primary research focus is in imaging methodology development and another investigator whose research is focused on biomedical science. At least one of the co-principal investigators should have a primary appointment in the School of Medicine. The TBIC adopts a broad definition of imaging science and seeks proposals that focus on anatomic or functional imaging approaches that span from the microscopic to in vivo regimes. Proposals that include a broad range of imaging methods including image acquisition techniques, image analysis, imaging probe development will be considered. Funding will be based on scientific merit, potential downstream clinical impact and the likelihood that the project will generate independent funding to sustain the effort. Post-pilot award outcomes will be surveyed. The deadline for applications is December 2, 2016, for an award start date of February 1, 2017.

For additional information, please visit our website or contact Drs. Mitchell Schnall at mitchell.schnall@uphs.upenn.edu,  James Gee at gee@mail.med.upenn.edu, or David Mankoff at mankoffd@mail.med.upenn.edu.

2013 Awardees

The Translational Biomedical Imaging Center (TBIC) of the Institute for Translational Medicine and Therapeutics (ITMAT) announces its third round of successful applications for Pilot Grants.

The mission of these grants is to help catalyze collaborations between primary imaging scientists and primary biomedical/clinical researchers that integrate novel imaging approaches to enhance translational science and medicine and thus assist investigators in obtaining key data to seek extramural funding.

Imaging phospholipases as indicators of COX-2 activation in breast cancer
James Delikatny, Radiology, Perelman School of Medicine
Emer Smyth, Pharmacology, Perelman School of Medicine

Integrating Imaging with Genomic Biomarkers for Breast Cancer Prognostication
Despina Contos, Radiology, Perelman School of Medicine
Carolyn Mies, Pathology and Laboratory Medicine, Perelman School of Medicine
Michael Feldman, Pathology and Laboratory Medicine, Perelman School of Medicine
Jinbo Chen, Biostatistics and Epidemiology, Perelman School of Medicine
Emily Conant, Radiology, Perelman School of Medicine

Imaging metabolic effects of kinase inhibitors in lymphoma patients
Seung Lee, Radiology, Perelman School of Medicine
Jerry Glickson, Radiology, Perelman School of Medicine
Stephen Schuster, Medicine-Hematology/Oncology, Perelman School of Medicine

Ultra-high resolution BOLD fMRI of medial temporal lobe at 7 Tesla
Sandhitsu Das, Radiology, Perelman School of Medicine
David Wolk, Neurology, Perelman School of Medicine
Jongho Lee, Radiology, Perelman School of Medicine
Paul Yushkevich, Radiology, Perelman School of Medicine

Imaging Tumor pH using Cerenkov Specific Contrast Agents
James Delikatny, Radiology, Perelman School of Medicine
Lewis Chodosh, Cancer Biology, Perelman School of Medicine
Joel Karp, Radiology, Perelman School of Medicine

In Vivo Magnetic Resonance Spectroscopy of Metabolic Stress Response Mediated Changes in Tumor Metabolism
Terrence Gade, Radiology, School of Medicine
Celeste Simon, Cancer Biology, School of Medicine
Mitch Schnall, Radiology, School of Medicine

Probing Right Ventricular Metabolic Abnormalities in Pulmonary Arterial Hypertension
Yuchi Han, Cardiology, Perelman School of Medicine
Richard Freifelder, Radiology, Perelman School of Medicine
Joel Karp, Radiology, Perelman School of Medicine

Enhancing Thermal Effects by Tunable Microbubbles for Antivascular Ultrasound
Daeyeon Lee, Chemical and Biomolecular Engineering, School of Engineering and Applied Sciences
Chandra Sehgal, Radiology, Perelman School of Medicine

Development of microdosimetry for alpha particle therapy
Daniel Pryma, Radiology, Perelman School of Medicine
Jon Maris, Pediatrics-Oncology, Perelman School of Medicine

Functional Connectivity and Persistant Dysfunction in Mild Traumatic Brain Injury
Doug Smith, Neurology, Perelman School of Medicine
John Detre, Neurology, Perelman School of Medicine

Implications of Obstructive Sleep Apnea on Neurovascular Reactivity Assessed by Time-Resolved MRI Oximetry
Felix Wehrli, Radiology, Perelman School of Medicine
Richard Schwab, Sleep Medicine, Perelman School of Medicine


For more information, please visit the ITMAT website.

Mitchell Schnall, MD, PhD, Director, TBIC
Garret A. FitzGerald, M.D., FRS, Director, ITMAT

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MHB Maturational Human Biology Pilot Grant Program

 Proposal due date: May 23, 2016 at 12pm.

The proposals must be interdisciplinary and translation in nature and bridge the pediatric to adult divide. All proposals must have at least two Co-Principal Investigators, including at least one from the University of Pennsylvania and at least one from The Children's Hospital of Philadelphia. The proposals are due May 23, 2016 at noon for a proposal start date of July 1, 2016.


JIPGP Junior Investigator Pilot Grant Program

 Applications due date: Friday, February 26, 2016, at 5 pm.

The Clinical and Translational Research Center (CTRC) is now accepting research proposals to be considered for the Junior Investigator Preliminary/Feasibility Grant Program (JIPGP).

The primary goal of the Clinical Translational Research Center (CTRC) Junior Investigator Preliminary/Feasibility Grant Program (JIPGP) is to encourage junior investigators to develop research projects that will ultimately lead to extramural funding and to a career in Clinical Translational Research Center-focused investigation. The JIPGP awards are designed to allow junior faculty members, and M.D., Ph.D. and D.M.D. post-doctoral trainees with appropriate mentors to obtain funds for pilot/preliminary data projects that are investigator-initiated, human-based, CTRC studies. Projects should address CTSA themes of multidisciplinary research, translational research and research across the age spectrum. It is anticipated that the award will lead to a competitive extramural grant application (such as an NIH K or R grant). The award is $20,000 over one or two years and includes subsidized CTRC services.

All grant templates are contained within the instruction pdf file. Please click on the paperclip if you cannot view the attachments.

The grants will be available at each institution effective July 1, 2016.

Award Dates:

  • Application Receipt Deadline: February 26, 2016 at 5PM
  • Notification of Award: April 11, 2016
  • Funding Period: 7-1-16 to 6-30-17

2013 Awardees (pdf)


PICAB Program in Comparative Animal Biology

 Application due date: Friday, December 2, 2016, at noon.

The Penn-CHOP CTSA Program in Comparative Animal Biology (PICAB) announces a new pilot grant program between veterinary and human medicine to advance translational therapeutics. Many naturally occurring diseases in domestic animals are sufficiently similar to human diseases that they can be used to evaluate the feasibility of novel treatments. The emphasis is on molecular medicine approaches to therapy (gene therapy, stem cells, recombinant proteins) with the goal of generating sufficient preliminary data to support extramural grant applications. These proposals require co-PIs from the veterinary and the medical faculty (PSOM or CHOP). One pilot grant of up to $45,000 is available start date of February 1, 2017. Grants are due at noon on Friday, December 2, 2016.

Investigators who would like advice on potential partners in the other school may contact Dr. John H. Wolfe via Emily Romick at 215-590-7030 or emromick@vet.upenn.edu.


TAPITMAT CBIT Chemical Biology in Translation

Awardees

2009 TAPITMAT-CBIT Award Recipients

 Inhibiting the c-Myb Protooncogene (pdf)
(Alan Gewirtz, MD, Department of Medicine, School of Medicine)

 A High-throughput Chemical Screen to Discover Modifiers of TDP-43 Cellular Toxicity in a Yeast TDP-43 Proteinopathy Model (pdf)
(Aaron Gitler, PhD, Cell and Developmental Biology, School of Medicine)

 High Throughput Screening of the BRCA1-Associated BRCC36 Metalloprotease (pdf)
(Roger Greenberg, MD, PhD, Department of Cancer Biology, School of Medicine)


2008 CBIT Awardees

Cellular High Throughput Screeing (HTS) Assay for Duchenne's Muscular Dystrophy (DMD) Therapy
(Tejvir Khurana, PhD, Physiology, SOM)

Identifying Novel Promoters of Human MSC Osteo-Chondrogenesis through Chemical Library Screening Applications for Tissue Engineering
(Robert Mauck, MD, Orthopaedic Surgery, SOM and Jason Burdick, PhD, Bioengineering, SEAS)

Screening of Small Molecule Inhibitors of Complement
(Wenchao Song, PhD, Pharmacology, SOM)


2007 CBIT Awardees

Detection of caspase activation in zebrafish embryos, a sophisticated vertebrate for high-througput screening (HTS) of radiomodifying agents
(Dr. Gary D. Kao, Radiation Oncology, SOM)

Identifying selective ligands for prostacyclin-thromboxane receptor heterodimers
(Dr. Emer M. Smyth, Ph.D., Pharmacology, SOM)

Synthetic chemistry of Alzheimer Disease modulators
(Amos Smith PhD Chemistry, SEAS and Virgina Lee PhD, Pathology SOM)

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TAPTIMAT CT³N Center for Targeted Therapeutics and Translational Nanomedicine

 Application due date: Friday, December 2, 2016, at noon.

CT3N invites PENN and CHOP researchers to submit competitive proposals for Pilot Grants by December 2, 2016. The goal of these Pilot Grants is to support early-stage experimental preclinical studies in targeted therapeutics and thus assist investigators in obtaining key data to seek extramural funding. The grants will be for up to $50,000 for one year, starting February 1, 2017. As part of the launch of CT3N as a new joint center between Penn Engineering and PSOM, a total of four awards will be made. Funds have been provided by SEAS, via a generous donation from the Brassington family, OVPR, and PSOM, via ITMAT.

Scope:
Preclinical (animal, cell culture and in vitro) experimental studies focused on the design of systems for targeted delivery of therapeutics and/or imaging agents and the identification of molecular targets for site-specific medical interventions. Proposals in the realms of both adult and pediatric biomedicine, and especially bridging the adult/pediatric medicine divide, are welcome. Collaborative proposals from investigators representing both the SEAS and PSOM, aimed at bridging engineering/material science and biomedical aspects of the targeted therapeutics are especially encouraged.

Eligibility:
Applicants must be based in the University of Pennsylvania and be a full-time faculty of PENN/CHOP. Joint proposals by co-PIs from PENN /CHOP and from associated CT3N members (Drexel, Temple, Jefferson, PSU) will be considered. Applicants must be members of ITMAT CT3N and provide a written commitment to CT3N activities, including weekly journal clubs and monthly work-in-progress seminars. The PI’s lab can be based at any PENN School or at CHOP. Faculty members from all ranks and tracks are eligible to apply. Investigators in the rank of Senior Investigators and Research Associate may apply on the condition of providing an approval letter from the Department Chair and a letter from the faculty member PI of the lab, assuring that a Research Associate’s project represents an independent new extension of the research area of this lab.  

2013 Awardees

The Center for Targeted Therapeutics and Translational Nanomedicine (CT³N) of the Institute for Translational Medicine and Therapeutics (ITMAT) announces its second round of successful applications for Pilot Grants.

The mission of these grants is to support early-stage experimental preclinical studies in targeted therapeutics and thus assist investigators in obtaining key data to seek extramural funding.
CT³N is directed by Drs. Vladimir Muzykantov and Andrew Tsourkas.

The development of gold nanoclusters for sensitive CT cell tracking
David Cormode, Radiology, Perelman School of Medicine
Victor Ferrari, Medicine-Cardiology, Perelman School of Medicine

Directed Evolution of a Single Chain Antibody Fragment with High Affinity for Human and Rat ICAM-1
Colin Greineder, Emergency Medicine, Perelman School of Medicine
Casim Sarkar, Bioengineering, School of Engineering and Applied Sciences

Tumor-targeted pH-responsive polymersomes
Zhiliang Cheng, Bioengineering, School of Engineering and Applied Sciences

Design of yeast-secreted clickbodies directed against paired tumor antigens to target nanoparticles.
Natalie Scholler, Obstetrics and Gynecology, Perelman School of Medicine

Predictive Computational Modeling Platform for Internalization of Functionalized Nanocarriers
Ravi Radhakrishnan, Biochemistry/Biophysics, Perelman School of Medicine


For more information, please visit the ITMAT website.

Vladimir Muzykantov, MD, PhD, Director, PTT
Andrew Tsourkas, Ph.D., Associate Director, PTT
Garret A. FitzGerald, M.D., Director, ITMAT

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TAPITMAT/CHIBE Pilot Grant Program

Enrollment:

Deadline: Friday, November 4, 2016 at 12pm.

The Institute for Translational Medicine and Therapeutics (ITMAT) and the LDI Center for Health Incentives and Behavioral Economics (CHIBE) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category.  It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion.  If you are interested, please visit the membership section of our website (http://www.itmat.upenn.edu/membership.shtml) for details.

The concomitant problems of under-enrollment and selective enrollment in randomized clinical trials (RCTs) often plague efforts to evaluate medical interventions. These problems often arise due to unexpected impediments to participant recruitment, which represents one of the largest costs of conducting RCTs. In recent decades, behavioral economics has provided considerable insights into how people make decisions, blending findings from economics and psychology to generate better descriptive and normative models of behavior. The goal of this pilot program is to help investigators at UPENN develop more successful strategies to increase the efficiency of clinical trial enrollment across a range of different types of interventions.

Connected Health:

Deadline: Friday, November 18, 2016 at 12pm.

The Institute for Translational Medicine and Therapeutics (ITMAT) and the LDI Center for Health Incentives and Behavioral Economics (CHIBE) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category.  It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion.  If you are interested, please visit the membership section of our website (http://www.itmat.upenn.edu/membership.shtml) for details.

The proposal must center on novel approaches to testing and delivering interventions to improve health outcomes or health behavior for people at high risk for poor health outcomes. The purpose of this RFA is to support research teams to do quick turnaround studies focused on improving the management of population-based health within Penn Medicine patients. These are designed to be relatively short-term projects to create a cycle for rapid learning and iterative improvement, with a planned duration for each pilot of 3 to 5 months.  Proposals are encouraged to use the Way to Health platform.  Way to Health is an integrated research platform that integrates information from wireless technologies, communications tools, and other applications to allow investigators to test ways of improving health behaviors and helping people keep on track to better health. Please see the attached document for more information.


SPIRiT (formerly PATS)

 Ideas Deadline: September 15, 2014
Invitation to Submit Full Application: TBD
Application Deadline: TBD
Award Start Date: TBD

CPHI/CEAR CTSA Pilot Grant Program

Deadline: Friday, May 6, 2016 at 5:00pm

The Center for Public Health Initiatives (CPHI) and the Community Engagement and Research (CEAR) core of the Clinical and Translational Science Award (CTSA) at the University of Pennsylvania are collaborating on a pilot grant program to fund research with public and community health relevance.

This call for proposals is to open faculty with significant public and community health-related experience at Penn and is intended to:

  • Foster interdisciplinary research in public health at Penn that will have meaningful results at the community level.
  • Assist in garnering external support for large-scale studies in the field of public health.
  • Encourage additional faculty and staff at Penn to become involved in public health research.
  • Identify the innovative methodologies in the field of public health that have the potential of informing local, state, and national policy and programming.

Applications are due May 6, 2016 by 5:00pm. Awarded grants will be in the range of $2,000 to $20,000.

All applicants should be submitted electronically to Sarah Green (shgreen@upenn.edu). Please see the attached call for proposals for complete details.

Internal and External Funding Opportunities

There are many internal and external funding opportunities available for faculty and students. These opportunities can be viewed via the School of Medicine's portal and via the University's U@Penn Research Portal. This new feature, which is part of U@Penn, provides a single portal for investigators and administrators that is aimed at facilitating accessibility to research information.