Past Featured Articles

2009

John M. Maris, MD
Identification of ALK as a major familial neuroblastoma predisposition gene
Nature advance online publication 24 August 2008 | doi:10.1038/nature07261; Received 21 April 2008; Accepted 14 July 2008; Published online 24 August 2008.
George Coukos, MD, PhD
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.
PNAS May 13, 2008 vol. 105 no. 19 7004-7009.

Qihong Huang, MD, PhD
Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Puré E, Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis.
Nature Cell Biology. 10: 202-10. 2008.
Charles P. O'Brien, MD, PhD
Prospects for a genomic approach to the treatment of alcoholism. Arch Gen Psychiatry. 65:135-44. 2008

Angel Pizarro, MSE
Haim H. Bau, Ph.D.
Schrlau MG, Falls EM, Ziober BL, Bau HH. Carbon nanopipettes for cell probes and intracellular injection. Nanotechnology 19: 015101-015105. 2008. Nat Biotechnol. 25:1127-1133. 2007.
Mariusz A. Wasik, M.D.
Zhang Q, Wang HY, Liu X, Wasik MA. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. Nature Medicine 13: 1341-1348. 2007. Genome Res.

Angel Pizarro, MSE
Jones AR, Miller M, Aebersold R, Apweiler R, Ball CA, Brazma A, Degreef J, Hardy N, Hermjakob H, Hubbard SJ, Hussey P, Igra M, Jenkins H, Julian RK Jr, Laursen K, Oliver SG, Paton NW, Sansone SA, Sarkans U, Stoeckert CJ Jr, Taylor CF, Whetzel PL, White JA, Spellman P, Pizarro A. The Functional Genomics Experiment model (FuGE): an extensible framework for standards in functional genomics. Nat Biotechnol. 25:1127-1133. 2007.
Kai Wang, PhD
Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SF, Hakonarson H, Bucan M. PennCNV: An integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res. 2007 Oct 5; [Epub ahead of print]

Hakon Hakonarson, MD, PhD
Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature. 448: 591-4. 2007. Epub 2007 Jul 15.

William DeGrado, PhD
Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. Computational design of peptides that target transmembrane helices. Science. 315:1817-22, 2007

Marina Cuchel, MD, PhD
Cuchel M, Bloedon LT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE, Rader DJ. Inhibition of microsomal triglyceride transfer protein in familial hyperbolas. N Engl J Med. 356:148-56, 2007.

Amy Brooks-Kayal, MD
Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci.26:11342-6,2006

Carl H. June, MD
Levine BL, Humeau LM, Boyer J, Macgregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA. 2006 Nov 7; [Epub ahead of print]

Dennis E. Discher
Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell , 2006 Aug 25; 126 (4): 677-89. PDF Article Supplementary Data Website

John H. Wolfe
Karolewski BA. and Wolfe JH. Genetic Correction of the Fetal Brain Increases the Lifespan of Mice with the Severe Multisytemic Disease Mucopolysaccharidosis Type VII. Mol. Ther. 2006 Apr 17; (in press).

Gang Zheng
Zheng G, Chen J, Li H, Glickson JD. Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents. Proc Natl Acad Sci USA. 2005; 102(49): 17757-62.

Gideon Dreyfuss, Ph.D.
Wan L, Battle DJ, Yong J, Gubitz AK, Kolb SJ, Wang J, Dreyfuss G. The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy. Mol Cell Biol. 2005 Jul; 25:5543-51.

Garret A. FitzGerald
Anticipating change in drug development: The emerging era of translational medicine and therapeutics. Nature Reviews Drug Discovery 4, 815-818 (2005).

Carl H. June
Rapoport AP, Stadtmauer EA, Aqui N, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June CH. Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med. 2005 Nov;11(11):1230-7.