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Welcome to the Institute for Translational Medicine and Therapeutics

The Institute for Translational Medicine and Therapeutics (ITMAT) was launched in early 2005; the first institute of translational medicine in the world. Originally housed in the School of Medicine, within which it spans all Departments and Divisions, ITMAT has now expanded to include investigators focused on clinical and translational research in all schools at Penn, the Children's Hospital of Philadelphia, the Wistar Institute, the Monell Institute and the University of the Sciences in Philadelphia. These partner institutions competed successfully in 2006 for the Clinical and Translational Science Award (CTSA) funded under the NIH Roadmap, designating ITMAT as the academic home for the program. Since its foundation, ITMAT has expanded to include more than 1,250 members and to comprise more than 100,000 nsf supporting programs, infrastructure and education in clinical and translational research. It is hoped that this website will continue to develop to function as a common portal for all investigators interested in translational research.

ITMAT was designed to cluster and expand the many existing entities which support translational research. These included the General Clinical Research Centers (GCRCs) in both Penn and CHOP which have now been integrated into the Clinical and Translational Research Center, the former Center for Experimental Therapeutics (CET), the educational courses in patient oriented and translational research, including the Masters Program in Translational Research (MTR), elements of the Office of Human Research (OHR) and newly developed resources which support the translational mission. Catalyzed by the CTSA, ITMAT is now home for new Centers in Bioinformatics in Translation (BIIT), Personalized Medicine in Translation (PERMIT), Translational Biomedical Imaging and Targeted Therapeutics and Nanotechnology (CT3N). Multiple new cores have been launched to support clinical and translational research and new programs have been fostered including several which span the pediatric - adult divide.

While our institute is active across the spectrum of clinical and translational research it has a particular focus in two areas: translational therapeutics and the study of physiology and disease that spans the pediatric – adult divide.

ITMAT has focused its translational endeavor on research which spans the translational gap from proof of principle in model systems to completion of studies of mechanisms of physiology or disease or of drug action and dosing in humans up to the conclusion of Phase II. Its objectives in this area of Translational Medicine and Therapeutics are (i) to increase the size and integration of the community of researchers operating within this space; (ii) to create for them a substantial and visible presence and a common home; and (iii) to address the infrastructural hurdles which they face.

ITMAT facilitates growth in the community of Penn researchers pursuing translational research (i) by direct recruitment into its own research space– a new Translational Research Building opened in spring of 2011; (ii) by adding to recruitment packages of other academic entities within Penn; and (iii) by fostering education in translational medicine and therapeutics.

ITMAT fosters the pursuit of translational medicine and therapeutics in the Greater Delaware Valley through interactions with investigators and administrators in academic institutions and the pharmaceutical and biotechnology industries. In this regard, ITMAT launched its International Symposium Series, in 2006. The topics of these meetings have included the nature of translational research, the personalization of medicine, and the emergence of the academic sector into the domain of drug discovery and drug development, global approaches to translational research, and the academic contribution to development of novel therapeutics in an era of reform. Last year's symposium focused on translational strategies in contemorary science.

ITMAT will hold its seventh annual International Symposium on Tuesday and Wednesday, October 16 and 17, 2012. This meeting is entitled "Systems Pharmacology and Translational Medicine". Presentations and video clips from the previous symposia are found at

ITMAT supports a monthly seminar series; the 2012/2013 program is listed at and has also sponsored workshops and funding support for interdisciplinary, translational programs in Biomedical Imaging, High Throughput Screening, Targeted Therapeutics and Entrepreneurship in Medicine.

ITMAT represents an exciting new departure for both basic and clinical researchers at Penn. Investigators are encouraged to interact with this website or to contact the Director or Associate Directors to offer suggestions for initiatives that might be pursued by the Institute and to suggest listings which might usefully be included on this website.

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