Antibody Labeling Services

The Penn CNSC is excited to offer Antibody Labeling Services, a Site-Specific conjugations for increased Antibody Binding Performance.

Why Site-Specific?

Site-specific labeling ensures uniform labeling of up to 2 labels per Antibody on the heavy chain.

Learn more about Site-Specific Antibody Labeling

Read Supporting Publications & Research on Site-Specific Antibody Labeling

Oligos / Click-Chemistry / Nanoparticles / Biotin / ELISA Plates... and more offered.

Tell us your Desired Conjugation and send us your Antibodies

The core is now offering site-specific antibody conjugation services. The benefits of site-specifically labeled antibodies are enabled by the oYo-Link antibody labeling technology, developed by AlphaThera.

Email for Inquiries

Site-Specific Conjugation Services for...

single bioton — **ELISA**
Up to **10x increase in Sensitivity**. For Direct and Sandwich ELISAs.

Azide — **Click-Chemistry**
Copper-free click chemistry, for simpler antibody labeling at your convenience.

VcMMAE ADC rapid screening — **Rapid ADC Screening**
Improve throughput and enhance cell-killing assay performance.

More Featured Technologies

Antibody-Oligo Conjugates for Single-Cell analysis

oYo-Link oligo graphic Label your antibody with custom ssDNA or dsDNA sequences, up to 80bp in length. For Immuno-PCR, Proximity Ligation Assays, Cell Barcoding, and other novel applications of Antibody-Oligonucleotide Conjugates. High-quality Oligos ordered from IDT. Label as little as 1ug of Antibody with Oligo per reaction.

Antibody-Oligo Inquiry

HyperBright Fluorescent

HyperBright Fluorescent Coming Soon. Please inquire.

Fluorescently labeled antibodies that perform up to 5x better than antibodies conjugated with Alexa dyes. No secondary antibody needed since the primary is directly conjugated. For 488nm and 647nm ex.

HyperBright Inquiry

Supporting HyperBright 488nm Data

Graph of fluorescence intensity to count and comparison to competitor antibody reaction ratio

CUT&RUN: Better than ChiP-Seq with MNase Conjugations

Co MNase Bioanalyzer Data for CUT&RUN graph valently conjugate MNase directly to antibodies and use for the CUT&RUN assay or other cell digestion assays. Epigenetic mapping is vastly improved with oYo-Link MNase. Low cell counts yield high DNA enrichment results.

MNase Conjugation Inquiry

MNase Bioanalyzer Data for CUT&RUN Assay

oYo-Link™ MNase successfully works for CUT&RUN assays and yields more highly-enriched target DNA fragments when compared to conventional non-covalent pG-MNase as indicated by Bioanalyzer profiling. The testing antibody including two Histone markers: IgG1: Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (Abcam, ab8898) and IgG2: Anti-Histone H3K27me3 antibody - ChIP Grade (Abcam, ab195477); and the IgG isotype control.

Our Conjugation Service is Free with the purchase of any oYo-Link Product

We label Antibodies in Any Buffer, at Any Concentration

labeling rxn
No need to worry about Purification

The Next-Gen of Antibody Labeling

Non Site-Specific (Traditional)

non site-specific antibody labeling — Non Site-Specific Labeling

heterogeneous surface immobilization — Heterogeneous surface immobilization

Site-Specific (oYo-Link™)

site-specific labeling — Site-Specific Labeling

All images on antibody labeling by AlphaThera.