ITMAT in the News

  • Dermatology Scientist Sarah Millar Receives 2016 FOCUS Award for the Advancement of Women in Medicine

    Friday, November 25, 2016

    Sarah E. Millar, PhD, the Albert M. Kligman Endowed Professor and vice chair for basic science research in the department of Dermatology at the Perelman School of Medicine at the University of Pennsylvania, has received the 2016 FOCUS Award for the Advancement of Women in Medicine.

  • Molecular "Pillars" Team Up to Protect Liver from Toxic Fat Buildup

    Thursday, November 17, 2016

    Now, a new study published online today in Cell Metabolism by a team led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism in the Perelman School of Medicine at the University of Pennsylvania, revealed a surprising relationship between two molecules – one that works to store fat and another that promotes fat burning for energy.

  • Suppressing Protein Alleviates Radiation-Induced Bone Loss in Animal Model

    Monday, November 7, 2016

    Radiotherapy destroys cancer cells using high-energy ionizing radiation to damage DNA and induce cell death. About two million patients per year in the United States – more than 50 percent of all cancer patients -- receive radiotherapy at some stage during their illness, either alone or in combination with chemotherapy, surgery, and targeted medicines.

  • Stressed-out Rats Consume More Alcohol, Revealing Related Brain Chemistry

    Friday, November 4, 2016

    Stress, defined broadly, is a well-known risk factor for later alcohol abuse; however, the brain chemistry underlying interactions between stress and alcohol remain largely unknown.

  • Stability of Exhausted T Cells Limits Durability of Cancer Checkpoint Drugs

    Thursday, October 27, 2016

    Checkpoint inhibitor drugs that boost the immune system to fight cancer owe part of their existence to infectious diseases. Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways -- cell surface receptors such as CTLA4 and PD-1 -- to slow immune cells and prevent their elimination by the host. 

  • Fatty Diet Activates Oldest Branch of Immune System, Causing Intestinal Tumors

    Monday, September 26, 2016

    A high-fat-diet-induced immune reaction causes inflammation leading to intestinal cancer in a mouse model – even among animals that are not obese -- according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

  • Penn Medicine Professor Receives Distinguished Service Award for the Irish Abroad

    Thursday, September 22, 2016

    Garret A. FitzGerald, MD, FRS, Chair of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine at the University of Pennsylvania, has received a 2016 Presidential Distinguished Service Award for the Irish Abroad. He is the first recipient in the new category of Science, Technology, and Innovation.

  • Genes Essential to Life Found in Mouse Mutants are Related to Many Human Disease Genes

    Thursday, September 15, 2016

    About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others.

  • Minorities, Women Less Likely to Receive Life-Saving Stroke Treatment, Penn-led Study Suggests

    Wednesday, September 14, 2016

    Minorities and women suffering from a stroke may be less likely to receive the clot-busting treatment tPA, known as tissue plasminogen activator, according to a new study from Penn Medicine and other institutions published today in the online issue of Neurology, the medical journal of the American Academy of Neurology. 

  • Penn Software Helps to Identify Course of Cancer Metastasis, Tumor "Evolution"

    Friday, September 9, 2016

    An interdisciplinary team from the Perelman School of Medicine and the Wharton School at the University of Pennsylvania developed Canopy, an approach to infer the evolutionary track of tumor cells by surveying two types of mutations derived from multiple samples taken from a single patient.

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