Garret A. FitzGerald, MD, FRS

Contact

Garret FitzGerald, M.D.

Phone: 215-898-1185
Fax: 215-573- 9135
Email: garret@upenn.edu
Website: www.med.upenn .edu/fitzgeraldlab

 


Our laboratory has two areas of interest—prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging. Perhaps the distinguishing feature of our groups is that we pursue interdisciplinary translational science with a focus on therapeutics. Thus, we work in different model systems – mammalian cells, worms, fish and mice – but also in humans. Ideally we develop quantitative approaches that can be projected from our experiments in the model systems to guide elucidation of drug action in humans. To this end, we have long utilized mass spectrometry, initially to target the arachidonate derived lipidome, but more latterly also the proteome.

Education

1974 MB, BCh University College, Dublin
1979 MSc (Statistics) School of Hygiene, University of London
1980 MD (Pharmacology) University College, Dublin

Research Summary

Currently, we are interested in several aspects of prostanoid research. We utilize a remarkably broad array of mutant mice to elucidate the biology of the two COX enzymes and the prostanoid receptors. We are particularly interested in the comparative efficacy and safety of pharmacological inhibition of COXs versus the microsomal PGE synthase– 1. We are interested in the potentially countervailing actions of prostanoids on stem cell differentiation and in elucidating the broader cardiovascular biology of prostaglandins D2 and F2α . Finally, besides inhibitors of mPGES–1 we are interested in the translational therapeutics of various receptor antagonists, aspirin and fish oils.

In the area of clock biology, we are probing the role of the clock in aging in mice and worms and using cell specific deletions of core clock components to look at how communication paradigms between discrete peripheral clocks influence cardiovascular biology and metabolism. Finally, we are taking systems approaches to investigate how perturbation of peripheral clocks result in central clock dependent phenotypes.

Finally, we are involved in the interdisciplinary PENTACON consortium designed to integrate basic and clinical research in 5 systems – yeast, mammalian cells, fish, mice and humans ( both in detail and at scale) – with the objective of predicting NSAID efficacy and cardiovascular hazard in patients.

Selected Key Publications

Lab Address

Institute for Translational Medicine and Therapeutics
3400 Civic Center Boulevard, Building 421
10th Floor, Room 122
Philadelphia, PA 19104-5158
Lab Telephone: 215-898-0255
Lab Fax: 215-573-9004

 

Fitzgerald Lab Group photo 2018

Links