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The primary objective is to produce a cadre of highly trained and sophisticated investigators adept in the skills necessary for the translational investigator; to prepare students for an academic career and to position them for future careers as successful academic researchers who will become leaders in their field of research interest.The research should be translational in nature and involve direct measurements on patient-derived samples or the use of innovative therapeutic or diagnostic techniques with laboratory-based elements. There should be demonstrable clinical relevance. The protocol is to be designed by the student under the direct supervision of the mentor. Where appropriate, dual mentorship should be considered; including a basic scientist expert in the technology being used and a clinical investigator expert in the condition being studied. The primary protocol should account for at least 75-80% of the student's commitment to the program.